The Lab

Exercise is medicine https://t.co/YlkCthIkko https://t.co/TJ002FJ548

17-Sep-2018

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Our study highlighted in @LabRoots @calpolypomona https://t.co/v9oapbw0oy

17-Sep-2018

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Exercise is Medicine https://t.co/fJmIJCsza5 https://t.co/heeDzoXONN

28-Aug-2018

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https://t.co/HOOgrFPBMT https://t.co/N4v2r0AWbU

26-Aug-2018

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High dose NSAIDS and muscular gains https://t.co/TwpBbscjT8 https://t.co/xKaOYbshiz

03-Nov-2017

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dr.eddiejo View On Instagram

A couple months ago I did a similar post on muscle growth and I wanted to share the same perspective as it relates to fat/adipose loss. As we undergo a caloric deficit to drive a loss of adipose mass, we can only assess (at least practically) the efficacy of a program by changes that are observable. And often times we grow impatient when there is a lack of observable change and are quick to label the program ineffective or we simply quit. But when you understand that the reduction of adipose tissue is a process that begins all the way down to the most micro level of the body, the molecular level, you would understand that there is a huge element of time and scale. The size and mass of adipose tissue is really (at least for the most part) composed of the size and mass of all of the associated cells/adipocytes (hundreds of thousands of them). The size and mass of a single adipocyte/adipose cell is determined by the total mass of "stuff" inside each cell. This stuff taking up intracellular space are the various molecules that have specific roles in the cell's functioning. A very large portion of the molecules found in adipose cells are fat/lipid molecules often arranged in a storage form called triglycerides. Caloric deficit is the most potent stimulus for increasing the catabolism/degradation and oxidation of these fat molecules that again make up the size and mass of the adipose cells. So the fundamental point of achieving observable reduction of adipose mass is to consistently drive the catabolism and oxidation of intracellular fats/lipids to eventually atrophy the adipose cell. Even with that, a sufficient amount of cellular atrophy needs to occur to see visual and observable changes in adipose tissue size and mass. As you can see, even a kg reduction in adipose mass would require A LOT of work at the molecular and cellular levels. On top of that, underlying these changes from molecular to whole-body levels are epigenetic modifications via environmental or lifestyle factors (e.g. exercise, nutrition, etc). Persistence and patience is key. Just because you don't see observable changes doesn't mean nothing is happening.